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Automated Chemoproteomic Workstation
ChomiX’s professional biological automation equipment AutoProtChemix can process 96 samples in batches each time, realizing full-process automation of protein extraction, quantification, probe labeling, protein purification, enzyme cleavage and separation. Compared with the existing process dominated by manual operation, this equipment can ensure the accuracy and stability of the experimental process.
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ChomiX®-ClickKit-Cu/BTTAA C （Click Chemistry Kit）
BTTAA is a new generation of strongly water-soluble ligand, widely used in the CuAAC reaction in solution, matching fluorescein, biotin and other azide-modified reporter groups
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Protein Absolute Quantification Analysis
Protein Absolute Quantification Analysis Absolute quantification analysis is a crucial technique in the field of proteomics, specifically designed to accurately determine the concentration or copy number of proteins or peptides in a sample. The core of this method lies in the precise calibration using known concentrations of standards (usually isotopically labeled peptides). Absolute quantification analysis is of significant importance for both basic biological research and clinical applicati... -
Targeted Proteomics Analysis
Targeted Proteomics Analysis Proteomics research can be classified into two branches based on whether its focus is specific to a certain class of proteins: targeted proteomics and untargeted proteomics. Targeted proteomics emphasizes precise and in-depth study of pre-defined target proteins, while untargeted proteomics aims to comprehensively detect all proteins in the sample, with the goal of discovering unknown protein types and potential biomarkers, and is therefore often referred to as di... -
Protein Qualitative/Quantitative Analysis
Protein Qualitative/Quantitative Analysis In the field of drug development, scientists have been dedicated to exploring innovative therapies for specific diseases. Differential protein analysis has become a key tool for gaining insight into disease molecular mechanisms, identifying effective therapeutic targets, and providing critical clues and scientific evidence for the discovery and development of novel drugs. This technology empowers researchers to systematically detect changes in protein... -
Protein Qualitative and Quantitative Analysis
Protein Qualitative and Quantitative Analysis As a core technology in modern biomedical research, protein qualitative and quantitative analysis, supported by the rapid development of mass spectrometry technology, has achieved precise identification and quantification of proteins. This technology plays a pivotal role in revealing the mysteries of life phenomena, exploring disease mechanisms, and discovering biomarkers. Currently, it is widely used in various fields: Biological Mechanism E... -
Serine/Threonine Post-Translational Modifications
Serine/Threonine Post-Translational Modifications Serine and Threonine Post-Translational Modifications (PTMs) refer to the chemical modifications that proteins undergo after synthesis, with phosphorylation and glycosylation being the most common forms of modification. The PTMs on serine and threonine residues mainly include phosphorylation and O-glycosylation. After modification, these amino acid residues can significantly alter the protein’s activity, stability, and interaction capabi... -
Lysine Post-Translational Modifications
Lysine Post-Translational Modifications Among the 20 amino acid residues in proteins, lysine (K) is one of the most common targets for various post-translational modifications (PTMs). With the rapid development of high-resolution mass spectrometry (MS) and immunoprecipitation purification techniques, multiple acylation reactions on lysine have been discovered in the past decade, including acetylation, succinylation, malonylation, glutarylation, crotonylation, butyrylation, and lactylation. Re... -
Cysteine Post-Translational Modifications Omics Analysis
Cysteine Post-Translational Modifications Omics Analysis Cysteine, with its remarkable reactivity, plays a pivotal role in protein structure and function. Serving as a nucleophilic reagent, redox catalytic center, metal ion ligand, and key site for conformational changes, it extensively participates in and profoundly influences protein activity and regulatory mechanisms. It’s worth noting that cysteine residues are prone to undergo various types of post-translational modifications (PTMs... -
Protein Post-Translational Modification (PTM) Omics Analysis
Protein Post-Translational Modification (PTM) Omics Analysis Over the past decades, researchers have discovered that the complexity of the human proteome far exceeds that of the genome. While approximately 20,000-25,000 human genes encode for over a million protein variants, this phenomenon arises from mechanisms such as gene recombination, selective transcription initiation, differential transcription termination, and splicing. Moreover, post-translational modifications (PTMs) play a crucial... -
Identification of interaction regions for protein-protein and antibody-antigen interactions
Identification of interaction regions for protein-protein and antibody-antigen interactions A profound understanding of protein structure and its interactions is crucial for revealing their biological functions. However, due to the complexity and diversity in the field of proteins, a single research technique often struggles to fully elucidate their mysteries. Therefore, biologists typically adopt a strategy of integrating multiple technical approaches to collectively explore the three-dimens... -
Identification of Protein-Protein Interaction Networks in Cells
Identification of Protein-Protein Interaction Networks in Cells Protein-protein interactions (PPIs) constitute an indispensable core component of cellular life activities, spanning multiple temporal and spatial dimensions and profoundly influencing crucial cellular processes such as cell cycle regulation, protein synthesis and secretion, signal transduction, and metabolism. Therefore, a deep investigation into protein interactions plays a pivotal role in uncovering the mysteries of molecular ...
